Investigation of 14 Food Allergen-Specific IgG Antibodies in 1299 Children

Patch testing and allergen-specific serum IgE and IgG antibodies in the diagnosis of canine adverse food reactions.

Adverse food reaction (AFR) is a common differential diagnosis for pruritic dogs. The only way to diagnose AFR is an elimination diet of 6-8 weeks with a protein and a carbohydrate source not previously fed. In humans, patch testing has been shown to be a useful tool to diagnose food allergies. In veterinary medicine, serum food allergen-specific antibody testing is widely offered to identify s...

Influence of allergen-specific immunotherapy on allergen-specific IgG subclasses in dogs with atopic dermatitis

Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries.

BACKGROUND Allergen-specific IgE and IgG antibodies play pivotal roles in the induction and progression of allergic hypersensitivity reactions. Consequently, monoclonal human IgE and IgG4 antibodies with defined specificity for allergens should be useful in allergy research and diagnostic tests. We used combinatorial antibody libraries and subsequent recombinant production to make and assess Ig...

Food allergen-specific serum IgG and IgE before and after elimination diets in allergic dogs.

Serum food allergen-specific antibody testing is widely offered to identify suitable ingredients for diets to diagnose adverse food reaction (AFR) in dogs with allergic skin disease. Antibody concentrations in blood samples obtained during an unsuccessful diet to help in the choice of diet changes may be influenced by the previous diet. The objective of this paper was to measure food antigen-sp...

Allergen-specific immunotherapy in children

HISTORICAL TIPS The science of “Immunology” originated in the 19th century and grass pollens were identified for the first time as the likely trigger of seasonal hay fever in the 1870s. Skin allergy testing became an accepted assessment technique around 1910. Immunoglobulin E (IgE) was identified in the 1960s. The first scholarly report of immunotherapy for allergy appeared by Noon and Freeman ...